The Linden Method Review - Linden Method Easy Explained - Sodium valproate

The Linden Method Review - Linden Method Easy Explained




people feel a bit nervous or anxious
from time to time
but it usually only happens on certain
occasions
like during potentially awkward situations
such as a first date...
or on a job interview
sadly for many of us nerves and anxieties can develop into full-blown
panic attacks which can be truly
overwhelming and make it difficult to
lead a normal life
panic attacks can feel like your body
is literally attacking you
you've chest can heart, you can have trouble
breathing
and your heart can race
it can be absolutely terrifying
and there are many different methods for
controlling a panic attack and anxiety
disorders
but many of them involve little more and
homegrown preventions
old wives tales
if you will or even extreme medication
sometimes these methods can be effective
but much of the time they simply aren't
if panic attacks and general anxiety are
stopping you from living the life you
want
then we have something just for you
a new way t completely cure yourself of
these horrible ailments
and the best thing is its success is
one hundred-percent guaranteed!
you might not have had to charles linden
although yiu might have read about his
successes in Vouge or Daily Mail or perhaps seen it on ITV
after developing severe anxiety which
led to some debilitating panic attacks
charles did what most of us would do
and spoke to his doctor
my doctor misdiagnosed as deppressed
and in the quick-fix waved it so often
happens
he immediately prescribed prescribeddiazepam
and mark my medical notes
hypochondriac
if i'd known then what i know now
i would have never gone to his surgery
that day
Charles was not suffering from depression
he was afflicted with an anxiety
disorder that was taking it his whole life
but since the problem was not being
correctly adressed
things got much worse
i had five years of diazepam addiction
stelazine
prozac, zispin and other
anti-depressants
i found myself very overweight
with acute anxiety
multiple medication addictions
food intolerance, extreme panic attack, up to ten a day
dpersonalization
drealization and agoraphobic to the
extreme
i'd visit every kind of specialist
quack , herbalist, alternative therapist
psychiatris,t psychologist
and non did give me a
spark of hope
although they all took huge amounts of
money from me
like many suffers
charles was unable to make any progress
using traditional methods so he
developed his own
it was a simple and straightforward way
of approaching the problem and it worked
charles approached his recovery with one
key fact in mind
he was not ill,he was not physically
or mentally ill
and neither was anyone else who suffers
from anxiety
anxiety and panic attacks are simply the
body's natural response to certain
situations
and because it's a natural response it
can be managed with the Linden Method
the linden method is an approach that's
almost revolutionary in its simplicity
i can show you have to stopp anxiety and
panic attacks from happening
more than a hundred and forty-eight
thousand people can now probably call
themselves ex-sufferers
thanks to my method
if we don't cure you
then we don't want your money
and of course i wouldn't say that if i
didn't know i can help
Charles Linden can help you take back to
life
he's helped thousands of people and he
can help you
click the link below for more
information!

https://www.youtube.com/watch?v=7fj-XrTt5uc


Sodium valproate




Sodium valproate or valproate sodium is the
sodium salt of valproic acid and is an anticonvulsant
used in the treatment of epilepsy, anorexia
nervosa, panic attack, anxiety disorder, posttraumatic
stress disorder, migraine and bipolar disorder,
as well as other psychiatric conditions requiring
the administration of a mood stabiliser. Sodium
valproate can be used to control acute episodes
of mania and acute stress reaction. Side effects
can include tiredness, tremors, nausea, vomiting
and sedation. The intravenous formulations
are used when oral administration is not possible.
In pregnancy, valproate has the highest risk
of birth defects of any of the commonly used
antiepilepsy drugs. However, some epilepsy
can only be controlled by valproate, and seizures
also pose grave risk to mother and child.
Some of the common adverse effects include
tiredness, tremor, sedation and gastrointestinal
disturbances. In addition, about 10% of the
users experience reversible hair loss. The
oral form is the only form available in the
US.
Safety in pregnancy
The risk of birth defects with valproate is
two to five times higher than other frequently
used antiepileptic drugs. Children born to
mothers using valproate have significantly
lower IQ scores. However, some epilepsy can
only be controlled by valproate, and seizures
during pregnancy can have grave consequences
for both mother and child. Doctors recommend
women who intend to become pregnant should
be switched to a different drug using combined
therapy if possible, which takes several months.
Women who are already pregnant and taking
high doses of valproate should try to lower
their doses.
All antiepileptic medications have been shown
to be associated with higher risks of fetal
abnormalities since at least 1983, with the
risks being related to the strength of medication
used and use of more than one drug.
Valproate has also been recognised as sometimes
causing a specific facial change termed andquot;fetal
valproate syndromeandquot;. Sodium valproate has
been associated with the rare condition paroxysmal
tonic upgaze of childhood, also known as Ouvrier-Billson
syndrome, from childhood or fetal exposure
(this condition resolved after discontinuing
valproate therapy.
While developmental delay is usually associated
with altered physical characteristics, this
is not always the case.
A 2005 study found rates of autism among children
exposed to sodium valproate before birth in
the cohort studied were 8.9%. The normal incidence
for autism in the general population is estimated
at less than one percent. Valproate may best
be avoided in women with localisation epilepsy,
where more effective and less risky alternatives,
such as carbamazepine, are available. A 2008
study also suggested a correlation between
higher rates of autism in children whose mothers
were treated for seizure disorders during
pregnancy using sodium valproate. However,
only 632 children were followed in this study,
prompting criticism that this study was too
small to determine whether a definitive correlation
existed between the use of sodium valproate
in pregnant mothers and higher autism rates
in their children, or whether other antiseizure
medications used during pregnancy may cause
this effect.
One multicentre trial in the UK and US compared
cognitive function in 309 children born to
mothers with epilepsy; it found sodium valproate
use was associated with an IQ level eight
points lower in children born to mothers taking
sodium valproate than mothers taking other
antiepileptic drugs. The authors of the study
attempted to correct for confounding factors,
but this was an observational study, so could
not prove a causal link. Proving a causal
link requires a randomised-controlled trial,
which is not ethical to perform. Stronger
evidence likely will not become available.
A class action lawsuit is currently underway
in the United Kingdom regarding the claim
that the drug used in pregnancy caused a range
of problems in children, including autism,
learning and social difficulties, ADHD, spinal
stenosis, facial abnormalities, vision defects,
dyslexia, developmental coordination disorder,
and delayed speech and motor development.
he U.S. Food and Drug Administration uses
a pregnancy category system to classify the
possible risks to a fetus when a specific
medicine is taken during pregnancy. Depakote
is in pregnancy Category D when used for the
treatment of epilepsy or manic episodes associated
with bipolar disorder.
Pregnancy Category D is a classification given
to medicines that have been shown to present
a risk to the fetus in studies of pregnant
women but may still offer benefits that outweigh
the risks that the drug presents. A pregnancy
Category D medicine may still be given to
a pregnant woman if the healthcare provider
believes that the benefits to the woman outweigh
the possible risks to the unborn child.
Depakote is in pregnancy Category X when used
for the prevention of migraine headaches.
Pregnancy Category X means that the risks
of taking the medication during pregnancy
clearly outweigh the benefits. Medications
in this category should not be taken by women
who are pregnant or planning on becoming pregnant.
Women who are taking Depakote for this reason
and become pregnant or plan on becoming pregnant
should contact their healthcare provider before
stopping the medication, as it should not
be stopped abruptly.
Many studies have shown that Depakote may
cause birth defects in humans. Sometimes,
these birth defects can be very severe.
Studies have also shown that children born
to women who took valproate medications during
pregnancy tend to score lower on andquot;cognitive
functionandquot; tests, compared to children whose
mothers took other epilepsy medications while
pregnant.
Pregnant women should not take Depakote unless
absolutely necessary. However, uncontrolled
epilepsy can also be dangerous to both a pregnant
woman and the fetus. You and your healthcare
provider must discuss the specific benefits
and risks of using Depakote during pregnancy
for your particular situation. If your epilepsy
is very mild, you may consider stopping Depakote.
However, if your epilepsy is severe or difficult
to control, it may be best for you to stay
on Depakote. No matter what, do not stop taking
Depakote suddenly.
If you and your healthcare provider decide
that it is best for you to continue taking
Depakote during pregnancy, you will need frequent
blood tests to measure your Depakote levels.
Pregnancy can affect the way your body handles
the drug, and it is important to keep your
dose at the lowest effective level. Your healthcare
provider may suggest a higher-than-usual dose
of folic acid, as this may also help protect
the fetus.
Safety for children
Two children developed severe cognitive and
behavioral deterioration suggestive of a degenerative
disease while being treated with sodium valproate
for idiopathic epilepsy. Magnetic resonance
imaging revealed multiple areas of brain atrophy.
In both patients, clinical symptoms and signs
cleared in a few weeks once they ceased taking
the valproate. The magnetic resonance imaging
appearance improved within 3 months in 1 of
the patients and normalized in both after
6 and 12 months. No metabolic changes were
associated with the clinical or imaging abnormalities.
Although the mechanism of this rare idiosyncratic
complication of valproate therapy is unknown,
we advocate discontinuing valproate therapy
in all epileptic patients with neuromental
deterioration or brain atrophy of unknown
etiology.
Mechanism of action
Sodium valproate is a weak blocker of sodium
ion channels; it is also a weak inhibitor
of enzymes that deactivate GABA such as GABA
transaminase. It may also stimulate the synthesis
of GABA, but the direct mechanism is not known.
Because of its many mechanisms of action,
sodium valproate has efficacy in all partial
and generalised seizures including absence
seizures.
Formulations
Trade names are in bold, followed by the manufacturer.
Portugal
Tablets â€" Diplexil-R by Bial.
United States
Intravenous injection â€" Depacon by Abbott
Laboratories.
Syrup â€" Depakene by Abbott Laboratories..
Depakote tablets are a mixture of sodium valproate
and valproic acid.
Tablets â€" Eliaxim by Bial.
Australia
Epilim Crushable Tablets Sanofi
Epilim Sugar Free Liquid Sanofi
Epilim Syrup Sanofi
Epilim Tablets Sanofi
Sodium Valproate Sandoz Tablets Sanofi
Valpro Tablets Alphapharm
Valproate Winthrop Tablets Sanofi
Valprease tablets Sigma
New Zealand
Epilim crushable tablets 100mg by Sanofi-Aventis
Epilim EC modified release tablets 200mg and
500mg by Sanofi-Aventis
Epilim Syrup 200mg/5mL by Sanofi-Aventis
Epilim Sugar Free Liquid 200mg/5mL by Sanofi-Aventis
Epilim intravenous solution 100mg/mL by Sanori-Aventis
All the above formulations are Pharmac-subsidised.
UK
Depakote Tablets
Tablets â€" Orlept by Wockhardt and Epilim
by Sanofi
Oral solution â€" Orlept Sugar Free by Wockhardt
and Epilim by Sanofi
Syrup â€" Epilim by Sanofi-Aventis
Intravenous injection â€" Epilim Intravenous
by Sanofi
Extended release tablets â€" Epilim Chrono
by Sanofi is a combination of sodium valproate
and valproic acid in a 2.3:1 ratio.
Enteric-coated tablets â€" Epilim EC200 by
Sanofi is a 200-mg sodium valproate enteric-coated
tablet.
UK only
Capsules â€" Episenta prolonged release by
Beacon
Sachets â€" Episenta prolonged release by
Beacon
Intravenous solution for injection â€" Episenta
solution for injection by Beacon
Germany, Switzerland, Norway, Finland, Sweden
Tablets â€" Orfiril by Desitin Pharmaceuticals
Intravenous injection â€" Orfiril IV by Desitin
Pharmaceuticals
South Africa
Syrup â€" Convulex by Byk Madaus
Tablets â€" Epilim by Sanofi-synthelabo
Romania
Companies are SANOFI-AVENTIS FRANCE, GEROT
PHARMAZEUTIKA GMBH and DESITIN ARZNEIMITTEL
GMBH
Types are Syrup, Extended release mini tablets,
Gastric resistant coated tablets, Gastric
resistant soft capsules, Extended release
capsules, Extended release tablets and Extended
release coated tablets
Concentrations are between 150mg and 1000mg
or 57,64mg/ml and 300mg/5ml
Canada
Intravenous injection â€" Epival or Epiject
by Abbott Laboratories.
Syrup â€" Depakene by Abbott Laboratories
its generic formulations include Apo-Valproic
and ratio-Valproic.
Japan
Tablets â€" Depakene by Kyowa Hakko Kirin
Extended release tablets â€" Depakene-R by
Kyowa Hakko Kogyo and Selenica-R by Kowa
Syrup â€" Depakene by Kyowa Hakko Kogyo
Europe
In much of Europe, Depakine and Depakine Chrono
are equivalent to Epilim and Epilim Chrono
above.
Taiwan
Tablets â€" Depakine by Sanofi Winthrop Industrie
Israel
Depalept and Depalept Chrono are equivalent
to Epilim and Epilim Chrono above. Manufactured
and distributed by Sanofi-Aventis.
India, Russia and CIS countries
Valprol CR by Intas Pharmaceutical
Encorate Chrono by Sun Pharmaceutical
See also
Valproate semisodium
References
External links
Chemical Land21: Sodium Valproate
RXList.com: Depacon
British National Formulary Edition 58
Med Broadcast.com: Epival
Drugs.com: Depaken Syrup

https://www.youtube.com/watch?v=7HVZ9nMunxc